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Osteogenic differentiation of the spinal ligament derived cells by dexamethasone

山口医学 Volume 49 Issue 6 Page 527-533
published_at 2000-12-30
B030049000602.pdf
[fulltext] 594 KB
Title
デキサメサゾンによる脊椎靭帯由来細胞の骨芽細胞系への分化誘導
Osteogenic differentiation of the spinal ligament derived cells by dexamethasone
Creators Murata Hidenori
Source Identifiers
Creator Keywords
脊椎靭帯骨化 骨芽細胞 分化 デキサメサゾン
Given the pathogenesis of ossification of the spinal ligament has been shown to be associated with osteogenic differentiation of spinal ligament cells, cells derived from human yellow ligament of the spine were investigated for their ability to develop osteoblast phenotypic markers in the presence of dexamethasone. Growth of the ligament cells was suppressed by the addition of dexamethasone at a high concentration (10^6 M). Dexamethasone increased alkaline phosphatase activity and mRNA levels of alkaline phosphatase and pro-α(I) collagen, suggesting that human spinal ligament consists of a heterogeneous population of cells including immature multipotential cells as well as committed fibroblasts, and that dexamethasone has a possible involvement in the osteoblastic differentiation of the former cells.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2000-12-30
Rights
本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである()
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
[isVersionOf] [NAID]http://ci.nii.ac.jp/naid/110002774036/
Schools 医学部