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he Influence of Adenylate Cyclase Activator, NKH477 on Endo-epicardial Function and Coronary Blood Flow During Coronary Hypoperfusion

山口医学 Volume 42 Issue 1 Page 37-49
published_at 1993-02
Title
心筋虚血時の冠血流と心内膜側及び外膜側心筋収縮に及ぼすAdenylate Cyclase Activator (forskolin) の効果について
he Influence of Adenylate Cyclase Activator, NKH477 on Endo-epicardial Function and Coronary Blood Flow During Coronary Hypoperfusion
Creators Ikeda Yasuhiro
Source Identifiers
Creator Keywords
水溶性 forskolin 誘導体 冠血流 局所心筋収縮 心筋虚血 アデニル酸シクラーゼ
To examine the effects of adenylate cyclase activation on epi-and endo-myocardial contraction and coronary blood flow (CoF) with or without ischemia, we measured coronary pressure (CoP), CoF by in-line electromagnetic flowmeter and epi-and endo-myocardial wall thickening (%EPWT & %ENWT by sonomicrometry) in 18 anesthetized dogs. Left circumflex coronary artery was servo-pump per fused with arterial blood. CoP was decreased stepwise from lOOmmHg to 40mmHg. Under the infusion of low dose forskolin derivative, NKH477 (F) (10^<-9>M/kg/min), CoF was not augmented at CoP=40mmHg, %ENWT tended to increase (6±7 vs. 12±7 %, n.s.) and the decremental rate of ENWT against CoP was significantly attenuated compared with control condition (0.74±0. 15 vs. 0.44±0.18, p<0.05), while that of %EPWT was not significantly attenuated. With the infusion of high dose F (10-8M/kg/min), both %EPWT and %ENWT were not significantly changed (%EPWT: 15±6 vs. 12±3%
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1993-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部