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The Formation of Cerebrospinal Fluid in Ventricular Perfusion with Hyperosmolar Fluid

山口医学 Volume 32 Issue 2 Page 173-186
published_at 1983-04
Title
高滲透圧液による脳室灌流時の髄液産生
The Formation of Cerebrospinal Fluid in Ventricular Perfusion with Hyperosmolar Fluid
Creators Ihara Kiyoshi
Source Identifiers
The effects of ventricular fluid hyperosmolality on the CSF formation rate were studied in anesthetized rabbits during ventriculocisternal perfusion. Perfusions were carried out with mock CSF or hypertonic perfusate which was prepared by adding various amounts of either NaCl or glucose to mock CSF. CSF formation rates during perfusions were linearly correlated to differences in osmolality between perfusate and blood plasma (osmotic gradient). The slopes of regression lines in both groups using NaCl (0.032μl/min/mOsm) and glucose (0.035) were similar. Concentration of Na^+ in nascent CSF was reversely correlated to the osmotic gradient in both groups. The slope of regression line was larger in NaCl group (0.585μl/min/mOsm) than in glucose group (0.164). Difference between these two coefficients was statistically significant. ^<22>NaCl and TOH were used as a tracer to estimate the movement of sodium and water from blood to CSF and from CSF to brain during normotonic and hypertonic perfusions. From the results obtained, it is concluded that the net flux of Na_+ into CSF may be regulated in response to osmolality and concentration of Na^+ in the intraventricular CSF. When osmolality of CSF increases, Na^+ is supposed to play a role as a protector against cerebral dehydration due to osmotic flow of water.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1983-04
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部