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Effects of RU 486 on the Early Luteal Function in Pseudopregnant Rats

山口医学 Volume 41 Issue 6 Page 395-400
published_at 1992-12
Title
偽妊娠ラットの初期黄体機能に対するRU486の影響
Effects of RU 486 on the Early Luteal Function in Pseudopregnant Rats
Creators Kawamoto Kazunori
Source Identifiers
Creator Keywords
ラット 偽妊娠 黄体昨日 プロゲステロン RU486
Effects of an anti-progesterone substance, RU 486, on the luteal function were studied in pseudopregnant rats. The 2mg/kg injection RU 486 between day 2 and 9 of pseudopregnancy could not affect on the ovarian function until day 8 (the ascending and the plateau phases) of pseudopregnancy, but did induce luteolysis on day 10 (the descending phase) of pseudopregnancy. On the other hand, the lOmg/kg injection of RU 486 rather induced ovulation, formed new corpora lutea resulted in the increase in serum progesterone levels on day 10 of pseudo- pregnancy. These results indicate that progesterone is an important factor to maintain the pseudopregnancy in rats.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1992-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部