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The effect of thyrotropin releasing hormone on local cerebral blood flow in humans

山口医学 Volume 40 Issue 3 Page 411-426
published_at 1991-06
Title
Thyrotropin releasing hormane (TRH) の局所脳循環に及ぼす影響 : 脳血流シンチグラフィによる検討
The effect of thyrotropin releasing hormone on local cerebral blood flow in humans
Creators Fudaba Hiroyoshi
Source Identifiers
The effect of thyrotropin releasing hormone on local cerebral flow (CBF) was examined in 33 patients with mild or mederate disturbance of consciousness (Japan coma scale : I-1~II-2). Clinical diagnoses of these patients were subarachnoid hemorrhage (14 cases) intracerebral hemorrhage (9 cases) and cerebral inferction (10 cases). TRH (1mg) was acministered intravenously twice a day for a week. CBF was measuredst chromic stage by single photon emissions computed tomography (SPECT) using N-isopropyl-^<123>I-p-iodoamphetamine (^<123>I-IMP). SPECT was performed at 20 minutes (early scan) and 4hours (delayed scan) after administration of ^<123>I-IMP. Local CBF was evaluated by relative perfusion rate (e-RPR), as defined by the following equation, on the early scan. E-RPR=(average RI counts of each cerebral lobe) / (avarage RI counts of cerebellar hemisphere) In regions with mild or moderate decrease of e-RPR, e-RPR and redistribution on the delayed scan significantly increased after TRH administration. In regions with normal or severe decrease of e-RPR, e-RPR and redistribution did not change after TRH administration. The effect of TRH ws the greatest in cases of subarachnoid hemorrhage. These results suggestet that TRH improved local CBF and the brain tissue viability which was disturbed midly or moderately in cases with cerebrovascular disease.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1991-06
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部