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Mechanisms of myeloma cell proliferation induced by interleukin-6

山口医学 Volume 51 Issue 4 Page 99-104
published_at 2002-08-31
B030051000401.pdf
[fulltext] 455 KB
Title
インターロイキン6による骨髄腫細胞の増殖機構
Mechanisms of myeloma cell proliferation induced by interleukin-6
Creators Ishikawa Hideaki
Source Identifiers
Creator Keywords
骨髄腫 細胞増殖 インターロイキン6 CD45 src型チロシンキナーゼ
Specific intracellular signals mediated by IL-6 receptor complexes, such as STAT3 and ERK1/2, are considered to be responsible for inducing a variety of cellular responses. In multiple myeloma, IL-6 only enhances the proliferation of CD45^+ tumor cells that harbor the IL-6-independent activation of src family kinases even though STAT3 and ERK1/2 are activated in response to IL-6 in both CD45^+ and CD45^- cells. Furthermore, the IL-6-induced prollferation of CD45^+ U266 myeloma cells is significantly suppressed by Lyn-specific antisense oligodeoxynucleotides or a selective src kinase inhibitor. These results indicate that the activation of both STAT3 and ERK1/2 is not sufficient for IL-6-induced proliferation of myeloma cell llnes that require src family kinase activation independent of IL-6 stimulation. Thus, the activation of the src family kinases associated with CD45 expression is a prerequisite for the proliferation of myeloma cell lines by IL-6. We propose a mechanism for IL-6 induced cell proliferation that is strictly dependent upon the cellular context in myelomas.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2002-08-31
Rights
本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである()
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
[isVersionOf] [NAID]http://ci.nii.ac.jp/naid/110002773718/
Schools 医学部