Mini-transplant and imatinib mesylate were temporarily effective in a patient with ph1 positive acute lymphoblastic leukemia which had been refractory to conventional chemotherapy

ミニ移植およびImatinib Mesylateが一時的に有効であった化学療法不応性フィラデルフィア染色体陽性急性リンパ性白血病の1症例

Mini-transplant and imatinib mesylate were temporarily effective in a patient with ph1 positive acute lymphoblastic leukemia which had been refractory to conventional chemotherapy

Creators Tominaga Takayuki

Creators Fukuda Naofumi

Creators Nakamori Yoshitaka

Creators Shimohakamada Yoko

Creators Taguchi Akihiko

Creators Miyazaki Mutsuko

Creators Shinohara Kenji

Mini-transplant was performed in a patient with Philadelphia chromosome (Ph1) positive acute lymphoblastic leukemia (ALL) which had been refractory to repeated courses of chemotherapy. Decrease of leukemic cells and mixed chimerism were observed during a first month. However, leukemic cells increased thereafter, and donor leukocyte infusion(DLI) was ineffective. Subsequently, Imatinib Mesylate was administered and leukemic cells decreased for 2 months, however lekemic cells increased thereafter. These treatments were temporarily effective for Ph1 positive ALL which was refractory to conventional chemotherapy. The improvement of these treatment strategies and accumulation of these cases are necessary.

本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである()

[ISSN]0513-1731

[NCID]AN00243156

[isVersionOf] [NAID]http://ci.nii.ac.jp/naid/110002773756/