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Metabolism and excretion of trichloroacetic acid as a metabolite of trichloroethylene in human subjects and rabbits

山口医学 Volume 36 Issue 6 Page 353-362
published_at 1987-12
Title
トリクロロエチレン特にその代謝産物トリクロロ酢酸の代謝・排泄
Metabolism and excretion of trichloroacetic acid as a metabolite of trichloroethylene in human subjects and rabbits
Creators Nakatsukasa Yasuo
Source Identifiers
The concentration of chloral hydrate (CH) and trichloroacetic acid (TCA) in the serum and urine in human subjects and rabbits were determioned after inhalation exposure to trichloroethylene (TRI). CH was detected only in the urine of the limited cases in both human subjects and rabbits the first day after TRI exposure, while not detected in the blood in all cases. TCA was detected in the serum and urine throughout more than a week after TRI exposure, while became undetectable in the urine earlier than in the blood. The pharmacokinetics of TCA administered in the blood of the rabbits were similar to that observed after TRIexposure. The total amounts of TCA excreted in the urine were only less than 20% of the administered doses. A decrease in TCA concentration and an increase in chlorine (Cl) concentration were seen in the TCA solution which was incubated at 37℃ after rabbit liver homogenate was added. Furthermore, an increased Cl excretion in the urine of rabbits was observed after intravenous administration of TCA. The results mentioned above indicate that Cl is a major metabolite of TCA.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1987-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部