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Effect of intraperitoneal administration of lentinan on rats with carcinomatous peritonitis

山口医学 Volume 40 Issue 1 Page 133-142
published_at 1991-02
Title
癌性腹膜炎モデルラットに対するlentinan 腹腔内投与の検討
Effect of intraperitoneal administration of lentinan on rats with carcinomatous peritonitis
Creators Yoshino Shigefumi
Source Identifiers
The aim of this study is to assess the effect of intraperitineal administration of lentinan on rats with malignant ascites and to investigate the immunological machanism which leads to the prolongation of survival time. Donryu rats (6 weeks of age, famale) bearing AH13, AH130, AH66, AH66F carcinomatiosis received intraperitoneal injection of lentinan (1mg/kg) or saline alone beginning one day agter tumor challenge. Survival was significantly prolonged in rats bearing AH13 by administration of lentinan (P<0.05). Therefore rats bearing AH13 were used in this study. The schedule of lentinan or saline administration was same as above. Immunological parameters such as subsets(OX^19+, W3/25^+, OX8^+) of blood lymphocytes(BL) and peritoneal exudate lymphocytes (PEL), and cytotoxic activities of blood mononuclear cells (BMC) were measured in lentinan group (L group), saline group no difference in each group, whereas in L group, the percentage of suppresor/cytotoxic T cells of PEL was increased. Anti-AH13 activities of BMG were lower as compared with NB and C group. These results indicate that cytotoic T cells play an important role on tumor regression in the perotoneal cavity. Intraperitoneal administration of Lentinan may by a new effective immunotherapy for carcinomatous peritonitis in humans.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1991-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部