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Experimental Study on Right Ventricular Function : Right Ventricular Systolic Time Intervals in Acute Pulmonary Embolism

山口医学 Volume 25 Issue 3-4 Page 135-146
published_at 1976-12
Title
右室機能に関する実験的研究 : 急性肺塞栓症における右室収縮時間について
Experimental Study on Right Ventricular Function : Right Ventricular Systolic Time Intervals in Acute Pulmonary Embolism
Creators Ozaki Masaharu
Source Identifiers
Right ventricular systolic time intervals (RVSTI) in experimentally produced acute pulmonary embolism were studied to evaluate right ventricular function. Acute pulmonary embolism was produced in 12 healthy adult mongrel dogs by injected carbon grains (50 to 100 microns in diameter) suspected in physiological saline into the right atrium of the dogs through a catheter. The amount of carbon grains suspention into the right atrium was increased monitoring pulmonary artery mean pressure (PAm). Measurements for determining right ventricular function were made when PAm, elevated by injecting the carbon grains suspention, was reached to a stable level. These measurements were repeated twice to 5 times at difference PAm levels in each dog. Subfractions of RVSTI, prejection period (PEP), ejection time (ET) and PEP/ET, were obtained analysing intracardiac pressure curves which were recorded during standard procedures of cardiac catheterization. To eliminate the contribution of heart rate, RVSTI subfractions were corrected by the regression equation obtained from control dogs in which PAm was below 19 mmHg. The cordiac output was measured by dye dilution method and aortic blood gas was analyzed. Findings of electrocardiogram and phonocardiogram were also investigated. The experimental procedures were completed without any heart failure. The elevation of PAm was accompanied with the increase of PEP/ET, prolongation of PEP and shortening of ET, in 10 of 12 subjects, until PAm was below 40 mmHg. However, when PAm was over 40 mmHg, the decrease of PEP/ET, shortening of PEP and prolongation of ET, were observed. The mean rate of right ventricular isovolumic pressure rise increased together with the elevation of PAm. This increase was accelerated by the elevation of PAm across 40 mmHg. Therefore, it is conclusive that the measurement of the RVSTI is useful for pathophysiological evaliation of acute pulmonary embolism.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1976-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部