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Pharmacological Actions and Their Computer Simulations

山口医学 Volume 32 Issue 6 Page 533-544
published_at 1983-12
Title
薬理作用とcomputer simulation
Pharmacological Actions and Their Computer Simulations
Creators Ban Takashi
Source Identifiers
Computer simulations were made in several aspects of pharmacological actions in terms of a receptor-occupancy. 1) Functional and competitive interactions of two drugs in combination which were at equilibrium states. 2) Relative change of fractional receptor-occupancy of two agonistic drugs after a sudden change in their affinities. 3) Relative change of fractional receptor-occupancy of agonists and slowly acting and fast acting antagonists which resulted in the ”paradoxical potentiation”. 4) Frequency dependent change in receptor-occupancy of a drug due to a state‐dependent change in affinity. Various drugs may differ with respect to their relative potency depending on the situations at which these drugs are applied. It is emphasized that the construction of an appropriate model is essential which can not only reproduce the experimental findings in terms of a few simple and meaningful parameters but also serve as a successful working hypothesis for the future work.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1983-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部