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Pharmacological and Toxicological Studies on Beclometasone dipropionate

山口医学 Volume 19 Issue 1 Page 65-86
published_at 1970-03
Title
Beclometasone dipropionateの一般薬理作用と毒性
Pharmacological and Toxicological Studies on Beclometasone dipropionate
Creators Ohguro Yuji
Creators Kiyohara Akira
Creators Miyagawa Akira
Creators Imamura Satoshi
Creators Koyama Kaoru
Creators Hara Takuji
Source Identifiers
Pharmacological, toxicological and teratological studies on a new topical corticosteroid, beclometasone dipropionate (KW-053), were experimentally conducted. The results obtained are summarized as follows : 1. Acute toxicity : KW-053, given by various routes, was remarkably recognized low toxicity. 2. Pharmacological studies : No pharmacodynamic effects of KW-053 were demonstrated. 3. Subacute and chronic toxicity : In the rat administered KW-053 subcutaneously, there were observed the characteristic changes of treatment with an anti-inflammatory steroid, but the changes produced by KW-053 300mg/kg/day corresponded with those by dexamethasone 1mg/kg/day. In the rabbit applied steroid-ointment or -cream to the skin, there were observed the changes, too, and the changes produced by KW-053 were slighter than those by dexamethasone.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1970-03
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部