Pharmacological and Toxicological Studies on Beclometasone dipropionate

Beclometasone dipropionateの一般薬理作用と毒性

Pharmacological and Toxicological Studies on Beclometasone dipropionate

Creators Ohguro Yuji

Creators Kiyohara Akira

Creators Miyagawa Akira

Creators Imamura Satoshi

Creators Koyama Kaoru

Creators Hara Takuji

Pharmacological, toxicological and teratological studies on a new topical corticosteroid, beclometasone dipropionate (KW-053), were experimentally conducted. The results obtained are summarized as follows : 1. Acute toxicity : KW-053, given by various routes, was remarkably recognized low toxicity. 2. Pharmacological studies : No pharmacodynamic effects of KW-053 were demonstrated. 3. Subacute and chronic toxicity : In the rat administered KW-053 subcutaneously, there were observed the characteristic changes of treatment with an anti-inflammatory steroid, but the changes produced by KW-053 300mg/kg/day corresponded with those by dexamethasone 1mg/kg/day. In the rabbit applied steroid-ointment or -cream to the skin, there were observed the changes, too, and the changes produced by KW-053 were slighter than those by dexamethasone.

[ISSN]0513-1731

[NCID]AN00243156