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Circulating anti-glycolipid antibodies in patients with heart disease

山口医学 Volume 37 Issue 5 Page 373-380
published_at 1988-10
Title
心疾患患者血清中の循環抗糖脂質抗体についての研究
Circulating anti-glycolipid antibodies in patients with heart disease
Creators Yoshinaga Toshiko
Source Identifiers
Circulating anti-glycolipid antibodies (c-AGLAb) were detected in the sera of 52 patients with heart-disease and 12 normal controls (NC) using thin-layer chromatogram (TLC)-immunostaining. The study population consisted of 7 patients with angina pectoris (AP), 8 with acute myocardial infarction (AMI), 17 with old MI (OMI), 19 with dilated cardiomyopathy (DCM), and 1 with hypertrophic cardiomyopathy (HCM). The indcidence of patients with c-AGLAb which reacted with glycolipids from human myocardium was 57.0% in AP, 25.0% in AMI, 29.0% in OMI, 26.3% in DCM, while that was not detected in N.C. This result suggests that the c-AGLAb were autoantibodies produced as a result of myocardial damage. By using silisic acid, and DEAE-Sepharose column chromatography with neuraminidase treatment, antigens which reacted with the c-AGLAb were found in both fractions of neutral glycolipids and gangliosides from human myocardium. On the other hand, c-AGLAb which reacted with these antibodies was higher in DCM, OMI, and AMI than in AP and NC, although the mechanism of the appearance of the antibodies under these pathological conditions is unclear. Further clinical evaluation of these c-AGLAb which readted with glycolipids of the human myocardium and of steer and/or sheep red blood cell membrane is necessary for the analysis of these heart disease.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1988-10
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部