Serum Concentration of Oral Disopyramide in Eight Inpatients.

入院患者8名における内服disopyramideの血中濃度

Serum Concentration of Oral Disopyramide in Eight Inpatients.

Creators Sawa Akihiro

Creators Imamura Akihisa

Creators Suetomi Katsutoshi

Creators Koshiro Akira

Monitoring of serum concentration of disopyramide, one of the useful antiarrhythmiacs, has been recommended because of a slight difference between therapeutic serum level (2-5μg/ml) and toxic level (over 7μg/ml). Measurments of serum concentration by high performance liquid chromatography were carried out as regards eight inpatients with cardiovascular disease. These patients were administered disopyramide capsuls (Rythmodan^<【○!R】> 100mg/Cap.) orally over 2 weeks in our hospital. The dosage ranged from 1.6 to 3.0 mg/kg (the mean : 2.1mg/kg) and the results obtained were as follows. 1. The average of apparent distribution volume (Vd) was 0.98L/kg (ranged from 0.69 to 1.46L/kg). 2. The mean serum concentration of steady state (Css) determined as 3.11μg/ml. 3. The steady state concentrations in each patients were all within therapeutic level and it was found that the medications by disopyramide are performed adequately.

[ISSN]0513-1731

[NCID]AN00243156