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Succinylcholine-Induced Increases in Plasma Catecholamine Levels in Man : Modification by Alcuronium Pretreatment

山口医学 Volume 35 Issue 1 Page 1-4
published_at 1986-02
Title
サクシニルコリンによる血中カテコラミン変動とアルクロニウム前処置の効果
Succinylcholine-Induced Increases in Plasma Catecholamine Levels in Man : Modification by Alcuronium Pretreatment
Creators Oshita Shuzo
Creators Tamura Hisashi
Creators Okamoto Kiyoshi
Creators Matsumoto Mishiya
Creators Masuda Tsutomu
Creators Funatsu Naohiko
Creators Ueda Satoko
Creators Hiraoka Izumi
Source Identifiers
The effects of succinylcholine alone (8 patients) or with alcuronium pretreatment (7 patients) on plasma levels of norepinephrine (NE) and epinephrine (E) were studied during enflurane anesthesia. Plasma levels of NE and E were determined immediately before and 1, 3, 5 and 10 min after intravenous administration of succinylcholine 1 mg/Kg. At the same time intervals, mean blood pressure and heart rate were measured. Blood gas values, enflurane and electrolytes concentration in the plasma were remained unchanged throughout the study. Without pretreatment, NE and E levels and mean blood pressure and heart rate increased significantly either at 1, 3 or 5 min after succinylcholine, and then returned to the control values at 10min. The peak increases in NE and E were 157% of control at 3 min and 177% 5 min, respectively. Alcuronium pretreatment attenuated the succinylcholine-induced increases in NE, E, mean blood pressure and heart rate. Although the underlying mechanism of the attenuation produced by alcuronium remains unclear, this study suggests that in clinical practice the use of succinylcholine must be cautious in patients with ischemic heart diseases.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1986-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部