Contents Menu

Immunogenetic Analysis of Stromal Herpetic Keratitis

山口医学 Volume 48 Issue 1 Page 3-11
published_at 1999-02
B030048000102.pdf
[fulltext] 4.72 MB
Title
実質型角膜ヘルペスの免疫遺伝学的解析
Immunogenetic Analysis of Stromal Herpetic Keratitis
Creators Makino Hajimu
Source Identifiers
Creator Keywords
実質型角膜ヘルペス HLA アリルタイピング
Almost everyone has experienced subclinical herpes simplex virus (HSV) infection by adulthood, however, only a limited number of individuals develop recurring stromal herpetic keratitis (SHK). It has been believed that the immune mechanisms participate in the etiology of SHK. The clinicoepidemiological characterization of SHK suggests that the sensitivity to HSV antigen in the cornea might vary among individuals. To clarify the etiological factor(s) in SHK, we investigated immunological background of the SHK patients based on their immunogenetic features. Immunogenetic background of the SHK patients and healthy control population was determined by HLA alleletypes using peripheral blood lymphocytes. Frequency of HLA-B*5 1 and -DRBI * 1405 in the SHK group were significantly increased as compared with those in the control group. The frequency of HLA-A*31, -A*33, -B*40 and HLA-DQB1*05031 seemed to be increased in the SHK group, though statistically not significant. Increased frequency of HLA-DRB1*1405 and HLA-DQB1*05031 among SHK patients seemed to result from the haplotype linkage with HLA-B*40. The clinicoepidemiological features of SHK were characterized by specific HLA class I alleles (HLA-A*31, -A*33, -B*40 and HLA-B*51), suggesting that the antigen tide specific immune mechanism mediated by CD8^+ T lymphocytes might participate in the etiology of SHK.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1999-02
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部