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Antifertility effect of sulfapridine in male rats

山口医学 Volume 38 Issue 5 Page 371-376
published_at 1989-10
Title
Suphapyridine 投与ラットにおける造精機能障害
Antifertility effect of sulfapridine in male rats
Creators Hayashida Hidetsugu
Source Identifiers
Salicylazosufapyridine (SASP), a drug used to treat uclerative colitis, reportedly depresses the fertility in males. But the mechanism od the action is still unknown. To make clear the infertility mechanism of sulphapyridine (SP), metabolite of SASP, male rats were force-fed SP (200mg kg). Extant of fertility was evaluated by the number of foetuses. Spermatogenesis was ecaluated by the flow cytometric DNA analysis of the testicular tissue. The number of ofetuses decreased significantly with SP treatment for 5 weeks and recovered 5 weeks after SP withdrawal. These data suggested that SP has the effect on the testis f suppresing spermatogenesis and that at least the testis is one of the target organs of SP-induced infertility.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1989-10
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部