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Effects of Human Fibroblast Interferon on Natural Killer (NK) Activities of 2 Patients with B Type Chronic Active Hepatitis

山口医学 Volume 32 Issue 4 Page 397-402
published_at 1983-08
Title
インターフェロン投与B型慢性肝炎2例におけるリンパ球NK活性の変化
Effects of Human Fibroblast Interferon on Natural Killer (NK) Activities of 2 Patients with B Type Chronic Active Hepatitis
Creators Morimoto Tetsuo
Creators Konishi Tomomi
Creators Kado Yuji
Creators Murata Makoto
Creators Matsuda Shoshi
Creators Fukumoto Yohei
Creators Kodama Takahiro
Creators Okita Kiwamu
Creators Takemoto Tadayoshi
Source Identifiers
Human fibroblast interferon (HFIF) was parenterally administered to two patients for 28 days. Two patients were diagnosed as chronic active hepatitis by liver biopsy, and had persistently positive HBsAg and HBeAg. They were R. Y. 23 years old male and K. H. 40 years old male. Total dosage of HFIF was 10.5×10^7 IU. Natural killer (NK) activity of peripheral blood lymphocytes and HBV markers were examined during administration of HFIF. NK activities of both patients had a tendency to fall. HBeAg became negative and a rise of HBeAb titer was found in case R. Y. But, HBsAg titer decreased little, and DNA-P activity had been negative before administration. In case K. H., DNA-P activity decreased transiently at 7th day after administration, but other HBV markers did not change. Transient thrombocytopenia, leukocytopenia and pyrexia were found during administration, but recovered promptly after the end of administration.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1983-08
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部