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Toxicological Studies on N_1-ethoxy Carbonyl-N_2-hydrazinophthalazine Hydrochloride (621-BT)

山口医学 Volume 18 Issue 1 Page 29-38
published_at 1969-03
Title
N_1-ethoxy carbonyl-N_2-hydrazinophthalazine hydroohloride (621-BT) の毒性実験
Toxicological Studies on N_1-ethoxy Carbonyl-N_2-hydrazinophthalazine Hydrochloride (621-BT)
Creators Koyama Kaoru
Creators Imamura Satoshi
Creators Ohguro Yuji
Creators Hatano Munetoshi
Source Identifiers
Toxicological and teratological studies on 621-BT were conducted. The results are summarized as follows. 1. Acute toxicity LD_50 of 621-BT given by various routes to mice, rats and rabbits is shown in Table-1. 2. Subacute and chronic toxicity 621-BT was administered orally to rats (SD-JCL) and rabbits (J. Albino) for 6 months, Fifty-percent mortality was observed within the 1st week in the group of rats receiving 350mg/kg and in the group of rabbits receiving 180mg/kg for 4 weeks. The death may have been due to hypotension caused by the treatment with 621-BT. The body weight gain was restrained in all groups. Slight normocytic anemia was found in the hematological examination. In addition, histological changes were observed in the lung, spleen and kidney within 3 months. However, there were no changes in the examination after 6 months. LE cells were not found at all, and there were no changes suggesting collagenosis.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1969-03
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部