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A study of radiosensitizing effect of misonidazole (Ro-07-0582) : 1. Radiosensitizing effect of Ro-07-0582 to Ehrlich Ascites Tumor Cell

山口医学 Volume 29 Issue 1 Page 25-29
published_at 1980-03
Title
Misonidazole (Ro-07-0582)の放射線増感効果に関する検討 第1報 : EATCにおけるRo-07-0582の放射線増感効果について
A study of radiosensitizing effect of misonidazole (Ro-07-0582) : 1. Radiosensitizing effect of Ro-07-0582 to Ehrlich Ascites Tumor Cell
Creators Kobayashi Mitsuaki
Creators Kawasaki Shoji
Creators Hashimoto Hiroyuki
Creators Toriihara Moriko
Creators Yokoyama Takashi
Creators Nakanishi Takashi
Source Identifiers
The radiosensitizing effect of Ro-07-0582 on the mean survival time of mice and mitotic delay time of the cells using the Ehrlich Ascites Tumor Cells were examined. Experimental method was undergone via in vitro or in vivo irradiation before in vivo assay. Under hypoxic condition containing Ro-07-0582, mean survival time of the mice was affected. In this instance, the enhancement ratio showed 1.85 in vitro and 1.95 in vivo. As for the mitotic delay time of the cells, low dose irradiation (from 50 rads to 200 rads) induced mitotic delay. Under the hypoxic condition containing Ro-07-0582, low dose irradiation showed just as twice mitotic delay time compared with the condition without Ro-07-0582. And so, the enhancement ratio of this circumstance was descided on 2.00. These conclusions showed that the drug of Ro-07-0582 had significant radiosensitizing effect under the hypoxic condition.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1980-03
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部