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Relationship of uric acid and uric acid to creatinine ratio with reduced glomerular filtration rate in non-alcoholic fatty liver disease among apparently healthy adults

Medical Science & Innovation Volume 71 Issue 1-2 Page 9-20
published_at 2024-06
A050071000102
[fulltext] 899 KB
Title
Relationship of uric acid and uric acid to creatinine ratio with reduced glomerular filtration rate in non-alcoholic fatty liver disease among apparently healthy adults
Abstract
Objective: The objective was to explore the potential existence and nature of the relationship between serum of uric acid (SUA) and serum uric acid to serum creatinine ratio (SUA/SCr) with reduced estimated glomerular filtration rate (eGFR) in patients with non-alcoholic fatty liver disease (NAFLD). Methods: A cross-sectional study was conducted among apparently healthy subjects with NAFLD (n=485). The association between tertiles of SUA and SUA/SCr with reduced eGFR (n=56) were investigated after adjustments for potentially relevant confounders. Also, the diagnostic performances of SUA and SUA/SCr were evaluated with the receiver operating characteristic (ROC) curve analysis. Results: In the adjusted models, SUA showed a significant positive association with reduced eGFR in the highest tertile (OR 5.65, 95% CI 2.48-12.86, p<0.001), and SUA/SCr, in the lowest tertile (4.21, 95% CI 1.76-10.07, p=0.001). The ROC curve analysis did not reveal any significant difference between the corresponding values of area under the curve for SUA and SUA/SCr (0.70 and 0.67, respectively; p=0.521). Conclusions: We revealed significant and independent associations of elevated SUA and reduced SUA/SCr with kidney function decline in NAFLD. However, the clinical utility of these two biomarkers seemed to be limited for the mentioned purpose and needs further investigations.
Creators Shimokawa Junki
Creators Mahbub MH
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Yamaguchi Natsu
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Hase Ryosuke
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Wada Sunao
Creators Saito Hiroyuki
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Watanabe Rie
Creators Matsumoto Shoko
Creators Nakagami Yuki
Creators Kurokawa Fumie
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Tanabe Tsuyoshi
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Source Identifiers
Creator Keywords
uric acid uric acid to creatinine ratio glomerular filtration rate nonalcoholic fatty liver disease
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2024-06
File Version Version of Record
Access Rights open access
Schools 大学院医学系研究科