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Rapid proliferation of CD22 negative leukemic cells after inotuzumab ozogamicin therapy for relapsed acute lymphoblastic leukemia

山口医学 Volume 70 Issue 4 Page 175-180
published_at 2021-12-02
B030070000404.pdf
[fulltext] 914 KB
Title
Inotuzumab ozogamicinの投与後にCD22陰性白血病細胞が急増した再発急性リンパ性白血病
Rapid proliferation of CD22 negative leukemic cells after inotuzumab ozogamicin therapy for relapsed acute lymphoblastic leukemia
Abstract
We report the case of a 48-year-old woman with relapsed B-lineage acute lymphoblastic leukemia(B-ALL)following cord blood transplantation, in which leukemic cell CD22 antigens became negative after a single administration of inotuzumab ozogamicin(InO).At relapse, a major part of leukemic cells expressed CD19 and CD22 antigens, however some leukemic cells were negative for CD22. As treatment with blinatumomab proved ineffective, InO therapy was subsequently initiated
Creators Sakai Kohei
Creators Tominaga Takayuki
Creators Nakano Kohei
Creators Matsumura Takuro
Creators Tanaka Shinsuke
Creators Takahashi Toru
Source Identifiers [PISSN] 0513-1731 [NCID] AN00243156
Creator Keywords
急性リンパ性白血病 CD22 イノツズマブ・オゾガマイシン
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2021-12-02
File Version Version of Record
Access Rights open access