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Experimental examination of the uptake, distribution and metabolism for trichloroethylene in the body

山口医学 Volume 43 Issue 2 Page 103-111
published_at 1994-04
Title
トリクロロエチレンの体内分布及び体内代謝に関する実験的研究
Experimental examination of the uptake, distribution and metabolism for trichloroethylene in the body
Creators Hobara Tatsuya
Source Identifiers
Creator Keywords
トリクロロエチレン 抱水クロラール トリクロロエタノール トリクロロ酢酸
In order to examine the uptake, distribution and metabolism of trichloroethylene(TRI) in the body, some kinds of experiments using anesthetized dogs were examined. About 50-60% of absorbed TRI was excreted from expired air for unchanged substance, and that of rest was metabolized in the body and excreted into urine and feces. About 18% of the absorbed the TRI would be metabolized to chloral hydrate(CH), trichloroethanol (TCE) and trichloroacetic acid (TCA) for one hour after the end of exposure, The abosorption rates of TRI from the intestine were very high levels. For this reason,TRI containing in the drinking water were almost absorbed in the body. The metabolism rates of the extrahepatic organs were about 25% of absorbed TRI. The metabolism from CH to F-TCE were mainly conducted in the extrahepatic organs.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1994-04
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部