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A close relationship between plasma concentrations of branched-chain and aromatic amino acids and uric acid among healthy adults

The bulletin of the Yamaguchi Medical School Volume 68 Issue 3-4 Page 31-39
published_at 2021
A050068000301.pdf
[fulltext] 555 KB
Title
A close relationship between plasma concentrations of branched-chain and aromatic amino acids and uric acid among healthy adults
Creators Ishimaru Yasutaka
Creators Mahbub MH
Creators Yamaguchi Natsu
Creators Hase Ryosuke
Creators Nakagami Yuki
Creators Takahashi Hidekazu
Creators Watanabe Rie
Creators Saito Hiroyuki
Creators Shimokawa Junki
Creators Yamamoto Hiroshi
Creators Kikuchi Shinya
Creators Tanabe Tsuyoshi
Source Identifiers [PISSN] 0513-1812 [EISSN] 2436-696X
Creator Keywords
branched-chain aromatic amino acids uric acid relationship
Purpose: The purpose of this study was to investigate the potential differences in plasma branched-chain and aromatic amino acid (BCAAs and AAAs) concentrations according to the levels of uric acid (UA) and determine the trends in such differences among apparently healthy subjects. Methods: Data from a total of 2804 healthy subjects were included in the current analysis and were categorized into three groups based on the tertiles of plasma UA level. The group differences for BCAAs and AAAs between UA tertiles were explored by analyses of variance (ANOVA) and covariance (ANCOVA). Results: There was a progressive increase in the concentrations of all BCAAs and AAAs from the lower to the upper tertiles. The group differences were significant for all amino acids investigated in this study (P<0.001) except for tryptophan. Overall, the differences were stronger in the higher quartile categories when compared with those for the corresponding lowest quartile category of individual BCAAs and AAAs. Conclusions: The current results suggest the potential existence of a close relationship of plasma levels of BCAAs and AAAs with UA, and warrant further research with elucidation of causal associations and interactions between them.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2021
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学)