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Investigation of Genetic Alterations in Brain Tumors by CGH

山口医学 Volume 48 Issue 5 Page 195-203
published_at 1999-10
B030048000502.pdf
[fulltext] 4.45 MB
Title
CGHによる脳腫瘍の細胞遺伝子学的解析
Investigation of Genetic Alterations in Brain Tumors by CGH
Creators Nishizaki Takafumi
Source Identifiers
Creator Keywords
CGH 脳腫瘍 染色体異常
Conparative genomic hybridization (CGH) is a technique which allowa the detection of losses and gains in DNA copy number along the entire genome. CGH wasused to study the genetic alterations in brain tumors. While 7p gain occurred exclusively in cases with the loss of all or part of chromosome 10, this change never occurred in cases having an increase in copy of 8q, which was the most frequently in younger patients than those with 7p gain. Our results provided evidence for distinct clinical manifestations in astrocytic tumors with 8q and7p gain. While typical meningiomas frequently displayed 22q loss, losses of 1p, 2p, 6q, chromosome 10and 14q, and gain of 20q were genetic changes implicated in the malignant progression of meningioma. While the most frequent aberration was loss of 13q with a minimal common overlapping region at 13q14 in pituitary adenomas, our results revealed that the mean number of sites of copy gain was significantly higher in functioning adenomas thanin non-functioning tumors. Further acquisition of genetic alterations were associated with unfavorable prognosis in patients with medulloblastomas. In this artcule, we discussed genetic alterations in brain tumors detected by CGH.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1999-10
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部