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An invited review following the soujinkai award : Cytochrome P450-generated metabolites of ω-3 fatty acids ameliorate choroidal neovascularization

The bulletin of the Yamaguchi Medical School Volume 62 Issue 3-4 Page 29-36
published_at 2015
A050062000302.pdf
[fulltext] 768 KB
Title
An invited review following the soujinkai award : Cytochrome P450-generated metabolites of ω-3 fatty acids ameliorate choroidal neovascularization
Creators Yanai Ryoji
Creators Sonoda Koh-Hei
Creators Connor Kip M.
Source Identifiers
Creator Keywords
ω-3 long-chain polyunsaturated fatty acids cytochrome P450 choroidal neovascularization immune cell recruitment
Age-related macular degeneration (AMD) is the primary cause of blindness in elderly individuals of industrialized countries, with a projected 50% increase in prevalence by 2020. There is an urgent need for new nutritional or pharmacological interventions that are safe over the long term for the treatment or prevention of AMD. Prospective clinical studies have suggested that dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) may protect against AMD. We recently characterized a mechanism by which dietary ω-3 LCPUFAs promote regression of choroidal neovessels in a well-characterized mouse model of neovascular AMD. The concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were increased in serum of mice fed a diet enriched in these ω-3 LCPUFAs. Cytochrome P450 enzymes catalyze the epoxidation of these primary ω-3 LCPUFAs to form 17,18-epoxyeicosatetraenoic acid and 19,20-epoxydocosapentaenoic acid, respectively, and intraperitoneal injection of these epoxyeicosanoids mimicked the beneficial effects of dietary ω-3 LCPUFAs on CNV resolution. Dietary intake of ω-3 PUFAs also suppressed leukocyte recruitment to CNV lesions by down-regulating endothelial expression of the adhesion molecules ICAM-1 and E-selectin as well as leukocyte expression of the ICAM-1 ligands CD11b and CD18. Bioactive lipid metabolites derived from ω-3 LCPUFAs thus show potential for the treatment or prevention of AMD.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2015
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学)