Contents Menu

A Case of Severe Aplastic Anemia Treated with Allogeneic Bone Marrow Transplantation

山口医学 Volume 33 Issue 6 Page 537-546
published_at 1984-12
Title
同種骨髄移植を施行した再生不良性貧血の一症例
A Case of Severe Aplastic Anemia Treated with Allogeneic Bone Marrow Transplantation
Creators Yamada Katsunori
Creators Shinohara Kenji
Creators Satoh Yutaka
Creators Yoshizaki Yoshiki
Creators Inoue Masamitsu
Creators Fujii Yasuhiko
Creators Kaneko Toshio
Creators Igarashi Mie
Creators Fujita Kyoko
Creators Kajii Tadashi
Creators Matsumoto Noboru
Source Identifiers
A 14-year-old female with severe aplastic anemia received allogeneic bone marrow transplantation (BMT) from HLA-identical brother. She was pre-conditioned with intravenous cyclophosphamide (50mg/kg/day, for 4 days) and low dose total body irradiation (300 rad) followed by infusion of bone marrow cells (3.5×10^<10> nucleated cell and 5.3×10^6 CFU-C). The reconstitution of hematopoiesis appeared on day 17 and engraftment was certified by an analysis of sex chromosomes on day 21. This engraftment, however, was unsustained because of the late rejection charactarized by bicytopenia occurred on day 50. Severe acute graft versus host disease (GVHD) of grade IV appeared after BMT. Skin lesion developed on day 10 and extended to generalized erythroderma with epidermal necrosis. Liver and enteric lesions developed on day 34 as 11mg/dl of hyperbilirubinemia and 3000ml/day of diarrhea, respectively. High grade fever persisted during her hospital course and she died of intracranial hemorrhage on day 58. Autopsy findings revealed total denudation of epithelium of skin and intestine, extensive hepatocellular necrosis and small bile duct injury, and disseminated cytomegalovirus infection.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1984-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部