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The Role of Epidermal Growth Factor (EGF)/Transforming Growth Factor (TGF)-α in the Development of Peptic Ulcer Disease, Malignant Tumors and Malignant Ascites.

The bulletin of the Yamaguchi Medical School Volume 42 Issue 3-4 Page 55-58
published_at 1995-12
A020042000302.pdf
[fulltext] 336 KB
Title
The Role of Epidermal Growth Factor (EGF)/Transforming Growth Factor (TGF)-α in the Development of Peptic Ulcer Disease, Malignant Tumors and Malignant Ascites.
Creators Omura Eiji
Source Identifiers
Creator Keywords
EGF TGF-α peptic ulcer diseases cancer ascites
Growth factors are proteins that modulate cell proliferation and other cellular functions. Many of these factors are polypeptides, and they include epidermal growth factor (EGF) and transforming growth factor (TGF)-α. EGF and TGF-α are members of EGF family, which also contains heparin-binding EGF-like growth factor (HB-EGF), amphiregulin and betacellulin (1, 2). The mature 53-amino-acid EGF is released from the 1,217 amino acid transmembrane precursor by proteolytic cleavage steps. TGF-α mRNA encodes a 160-amino acid transmembrane precursor which contains the mature 50-amino-acid TGF-α. The amino acid sequence homology between EGF and TGF-α is 35%. They both bind to the glycosylated 170-kDa cell surface membrane receptor, and their biological activities are exerted through this receptor. EGF is mainly systhesized by the salivary glands and the kidney (1). TGF-α, on the other hand, was initially thought to be produced by transformed cells and embryonic tissues. However, surveys of TGF-α mRNA expression and protein localization have shown widespread distribution of TGF-α in normal cells and tissues, including activated macrophages, keratinocytes, mammary epithelial cells, the anterior pituitary and most gastrointestinal cells and tissues (2). This report summarizes our studies, which have focused on the role of EGF and TGF-α in the development of diseases, such as peptic ulcer disease, malignant tumors and malignant ascites.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1995-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部