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Actue toxicity of insecticidal Methomyl in rats

山口医学 Volume 36 Issue 4 Page 233-251
published_at 1987-08
Title
カーバメート系殺虫剤メソミルの急性毒性に関する実験的研究
Actue toxicity of insecticidal Methomyl in rats
Creators Higashihara Eiji
Source Identifiers
Hematological, biochemical and histopathological examinations were conducted on rats administered orally 5, 10 and 15 mg/kg of Methomyl. Furthermore, mechanism of the toxic action of the drug was investigated. 1. Serum cholinesterase activity was inhibited and the clinical signs that could be associated with anticolinesterase activity appeared on animals after administration of each dose of the drug. 2. No hematological changes were observed. 3. Biochemical studies revealed the disorders in functions of livers and kidneys of rats receiving 5 mg/kg of Methomyl. Histopathological alterations were seen in lungs of rats administered 5 mg/kg and over of Methomyl, and also in livers and kidneys of animals which received 15mg/kg of the drug. 4. Rats administered 5 mg/kg and over of methomyl had a decrease in superoxide dismutase activity, an increase in serum lipoperoxide level and a decrease in serum α-tocopheraol level. The results abtained suggest that superoxide free radical may be concerned in the lesions of lungs, livers and kidneys of animals which received the drug. 5. Alpha-tocopheraol reduced the lesions of lungs, livers and kidneys of administered Methomyl.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1987-08
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部