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Fever, Leukopenia and Autoantibody Complications in a Patient with Silicosis Successfully Treated with Prednisolone

The bulletin of the Yamaguchi Medical School Volume 53 Issue 3-4 Page 45-48
published_at 2006-12
A050053000304.pdf
[fulltext] 537 KB
Title
Fever, Leukopenia and Autoantibody Complications in a Patient with Silicosis Successfully Treated with Prednisolone
Creators Matsui Kumiko
Creators Tanaka Yoshinori
Creators Matsuda Kazuhiro
Creators Shinohara Kenji
Source Identifiers
Creator Keywords
fever leukopenia autoantibody silicosis
A 71 year-old-male was admitted to our hospital because of fever accompanied with leukopenia. He was initially treated with antibiotics, without success. He had worked as a stone mason since the age of 20 was diagnosed as having silicosis at the age of 30. A polyclonal increase of immunoglobulins and elevations of antinuclear factor, anti-DNA antibody, and rheumatoid factor were documented, but anti-topoisomerase I(anti-topo I) antibody and PR3- and MPO- antibeutrophil cytoplasmic antibodies (ANCAs) were negative. HLA-DQB1 was *0301/*0502. Administration of prednisolone was effective for ameliorating fever and leukopenia. These results suggested the immunological pathogenesis for these symptoms with silicosis by interections of silica, antigen presenting macrophages and T-cells through specific HLA, and stimulation of B-cells to produce autoantibodies.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2006-12
File Version Version of Record
Access Rights open access
Relations
[isVersionOf] [URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools 医学部