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Effects of Hepatic Enervation on Glutathione Homeostasis after Lipopolysaccharide Addition in Rats.

山口医学 Volume 48 Issue 5 Page 205-212
published_at 1999-10
B030048000503.pdf
[fulltext] 3.73 MB
Title
肝除神経におけるグルタチオンの代謝について
Effects of Hepatic Enervation on Glutathione Homeostasis after Lipopolysaccharide Addition in Rats.
Creators Takao Koichiro
Source Identifiers
Creator Keywords
肝移植 肝除神経 グルタチオン エンドトキシンショック フリーラジカル
The tripeptide glutathione (GSH) is an important nonprotein thiol that plays multiple critical functional roles, and is a scavenger of superoxide in cells. Hepatic transport of glutathione is an essential process in the interorgan homeostasis of GSH. Hepatocellular G~SH is available to other extrahepatic organs. The present study examined the effects of hepatic nerve on GSH homeostasis after lipopolysaccharide (LPS) addition. A systemic depletion of GSH was observed in a denervated liver model compared with normal liver. Of particular interest was the observation that GSH was significantly decreased in the adrenal gland. This result exhibited that hepatic denervation diminished GSH concentration in other organs, resulting in these organs being vulnerable to the effects of active oxygen species. GSH concentration following LPS addition was significantly decreased in the normal liver. In contrast, LPS augmented the GSH concentrations in these organs in the denervated liver. These results were not yet sufficient to conclude whether the effects of hepatic denervation were favorable. However, it can be concluded that hepatic denervation causes the collapse of GSH homeostasis.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1999-10
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部