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Melatonin protects oocyte from reactive oxygen species

The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4 Page 43-51
published_at 2012
A050059000304.pdf
[fulltext] 1.24 MB
Title
Melatonin protects oocyte from reactive oxygen species
Creators Tamura Hiroshi
Creators Takasaki Akihisa
Creators Taketani Toshiaki
Creators Tanabe Manabu 
Creators Kizuka Fumie
Creators Lee Lifa
Creators Tamura Isao
Creators Maekawa Ryo
Creators Aasada Hiromi
Creators Yamagata Yoshiaki
Creators Sugino Norihiro
Source Identifiers [PISSN] 0513-1812 [NCID] AA00594272
Creator Keywords
melatonin oocyte ovulation reactive oxygen species antioxidant
Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night by the pineal gland, and it regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction. Melatonin is believed to regulate ovarian function by the regulation of gonadotropin release in the hypothalamus-pituitary gland axis via its specific receptors. However, it has been discovered that melatonin is a powerful direct free radical scavenger and a broad-spectrum antioxidant. High concentrations of melatonin have been found in human preovulatory follicular fluids. This study focused on the intra-follicular role of melatonin as an antioxidant in the ovary. Reactive oxygen species (ROS), which are locally produced during the ovulatory process, seem to play an essential role on follicle rupture. However, excess ROS can also be responsible for oxidative stress
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2012
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部附属病院 大学院医学系研究科(医学)