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Troglitazone-Induced Liver Injury Diagnosed by a Laparoscopic Examination in Its Asymptomatic Stage

The bulletin of the Yamaguchi Medical School Volume 46 Issue 1-2 Page 41-44
published_at 1999-06
A020046000106.pdf
[fulltext] 1.75 MB
Title
Troglitazone-Induced Liver Injury Diagnosed by a Laparoscopic Examination in Its Asymptomatic Stage
Creators Inoue Yasushi
Creators Yamada Tetsuya
Creators Katsuki Kensaku
Creators Kato Akira
Creators Kodama Takahiro
Creators Kamei Toshiaki
Source Identifiers
Creator Keywords
troglitazone diabetes mellitus liver injury
A 56-year-old diabetic woman had been taking glibenclamide (10 mg daily) plus voglibose (0.6 mg daily) for recent 4 years without a successful response. Three months after troglitazone (400 mg daily) was started in addition to glibenclamide, liver dysfunction was found by chance. She demonstrated no symptoms, histological examination, however, revealed a substantial hepatocelluar necrosis mainly in the peri-central vein areas, which was consistent with an idiosyncratic drug reaction. Since troglitazoneinduced liver dtsfunction was strongly suggested, administaration of troglitazone was terminated and abnormal values of liver-chemistry returned to normal in two months.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1999-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部