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Elevated Plasma Homocysteine is One of the Risk Factors for Sudden Cardiac Death in Japanese

The bulletin of the Yamaguchi Medical School Volume 49 Issue 3-4 Page 81-86
published_at 2002-12
A020049000306.pdf
[fulltext] 185 KB
Title
Elevated Plasma Homocysteine is One of the Risk Factors for Sudden Cardiac Death in Japanese
Creators Tsuruta Ryosuke
Source Identifiers
Creator Keywords
Cardiac arrest Cardiopulmonary resuscitation (CPR) Out-of-hospital CPR
Objective Hyperhomocysteinemia has been reported to be independent risk factor for myocardial infarction and death in coronary artry disease in abroad. To investigate the clinical signficance of plasma homocysteine in Japanese sudden cardiac death, we assussud its levels in cardiopulmonary arrest victims caused by cardiac etiology. Methods Plasma homocysteine was determined by a high-performance liquid chromatograph with a fluorometric detector. Patients Homocysteine was determned by a cardiopulmonary arrest (CPA) victims and in 104 healthy ccontrol subjects. The CPA patients were classified in the three groups based on the etiology, I.e., cardigenic, noncardiogenic (such as bronchial asthma and subarachnoid hemorrhage), or accidental (such as asphyxia and hanging ) CPA group. Results Plasma homocysteine in cardiogenic CPA patients was higher than that in noncardiogenic and accidental CPA patients, or in healthy control subjects. Plasma homocysteine in healthy men was higher than that in healthy women. Additionaly, homcysteine levels decreased progressively with age in healthy subjects (p<0.05).Conclusion These results demonstrated that high plasma homocysteine is a significant risk factor for sudden cardiac death and that a warning is inevitable for male younger generation in japanese.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 2002-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部