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The Effect of Zinc on the Adrenal Gland with Special Reference to the Increasing Effect on Brain Excitability

The bulletin of the Yamaguchi Medical School Volume 22 Issue 2 Page 253-264
published_at 1975-06
A020022000207.pdf
[fulltext] 787 KB
Title
The Effect of Zinc on the Adrenal Gland with Special Reference to the Increasing Effect on Brain Excitability
Creators Santoki Yoshirou
Source Identifiers
1. The effect of zinc on the adrena1 gland with special reference to the increasing effect on brain excitability was studied in rats. 2. A single subcutaneous injection of zinc markedly decreased EST. This EST-lowering effect was lost in adrenalectomized rats. 3. Succesive subcutaneous injections of zinc markedly increased adrenal weight in intact rats and the weight of the contralateral adrenal gland inhibited by cortisone after unilateral adrenalectomy. 4. The most remarkable change in histochemical examination produced by zinc administration was a marked acceleration of ATP-ase arid alkaline phosphatase activities in the capillary wall including the reticuloendothelial cells in the adrenal cortex. 5. The histochemical findings of the adrenal medulla were not significantly changed by zinc administration. 6. From the above findings, it is concluded that the EST-lowering effect of systemical1y administered zinc is produced by the stimultibon of the adrenal cortex. Its possiale mechanism is discussed.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1975-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部