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Associations between markers of inflammation and cholinergic blockade and delirium in intensive care unit patients: A pilot study

The bulletin of the Yamaguchi Medical School Volume 55 Issue 3-4 Page 34-42
published_at 2008
A050055000303.pdf
[fulltext] 620 KB
Title
Associations between markers of inflammation and cholinergic blockade and delirium in intensive care unit patients: A pilot study
Creators Tsuruta Ryosuke
Creators Girard Timothy D
Creators Ely E. Wesley
Creators Fujimoto Kenji
Creators Ono Takeru
Creators Tanaka Ryo
Creators Oda Yasutaka
Creators Kasaoka Shunji
Creators Maekawa Tsuyoshi
Source Identifiers
Creator Keywords
delirium inflammation C-reactive protein (CRP) acetylcholine Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
The purpose of this study was to determine the associations of serum C-reactive protein (CRP) and plasma anticholinergic activity (PAA) with delirium in critically ill and injured patients. Prospective cohort study of 32 patients admitted a university-based intensive care unit. All patients were evaluated for delirium with the Confusion Assessment Method for the Intensive Care Unit, and blood was collected for measurement of serum CRP and PAA. These biomarkers and other factors, including patient demographics, intubation, and Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ and Sequential Organ Failure Assessment (SOFA) scores were compared between patients who developed delirium and those who did not. Furthermore, the levels of serum CRP and PAA were examined for correlation with each other. Intubated and mechanically ventilated patients were more likely to be delirious than non-intubated patients (p < 0.001). The APACHE Ⅱ and SOFA scores were significantly higher in delirious patients than in non-delirious patients (p = 0.007 and p = 0.04, respectively). Serum CRP levels were significantly higher in intubated patients (p < 0.02) as were PAA levels (p = 0.001). A moderately strong correlation was found between serum CRP and PAA in the enrolled patients (Spearman's rho = 0.65, p<0.0001). Inflammation and cholinergic blockade, as measured by serum CRP and PAA levels, respectively, were associated with delirium in this study of critically ill patients, and serum CRP and PAA were correlated with each other.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2008
File Version Version of Record
Access Rights open access
Relations
[isVersionOf] [URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools 医学部附属病院 大学院医学系研究科(医学)