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Integrin alpha2 on the surface of tumor cells alter sites of metastases

The bulletin of the Yamaguchi Medical School Volume 57 Issue 1-2 Page 1-7
published_at 2010
A050057000101.pdf
[fulltext] 1.04 MB
Title
Integrin alpha2 on the surface of tumor cells alter sites of metastases
Creators Yoshimura Kiyoshi
Source Identifiers
Creator Keywords
integrin metastasis cancer liver
The finding that integrin α2 expression on tumor cells confers increased metastatic potential to certain tissue sites via direct physical adhesion, as well as the finding of the activation of an intracellular signaling cascade linked to integrin α2 that yields an invasion and growth phenotype is novel. These findings can potentially be exploited to increase our knowledge of which patients are at higher risk of forming (hepatic) metastases, thus aiding our ability to discriminate proper adjuvant therapy besed on molecular phenotyping. Additionally, expression of this cell surface molecule may be blocked, or the internal signaling cascade that results from binding of this cell surface molecule may be blocked to potentially decrease the metastatic potential of cancers in a therapeutic fashion.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2010
File Version Version of Record
Access Rights open access
Relations
[isVersionOf] [URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools 医学部附属病院 大学院医学系研究科(医学)