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Identification of the copy number aberrations for determining the disease stage of colorectal cancers : the application of a multifactor dimensionality reduction (MDR) method to an array-based CGH

The bulletin of the Yamaguchi Medical School Volume 56 Issue 3-4 Page 49-55
published_at 2009
A050056000305.pdf
[fulltext] 232 KB
Title
Identification of the copy number aberrations for determining the disease stage of colorectal cancers : the application of a multifactor dimensionality reduction (MDR) method to an array-based CGH
Creators Nakao Motonao
Creators Sasaki Kohsuke
Source Identifiers
Creator Keywords
array based CGH multifactor dimensionality reduction (MDR) method cross validation test
The clinical application of array CGH technology is eagerly awaited. It is necessary to clarify the genome markers closely associated with the clinical condition. The multifactor dimensionality reduction method (henceforth, MDR) analysis was applied to the array CGH data of 74 cases colorectal cancer in order to identify two or more spot clones, i.e., a clone marker, with the maximum separation ability between low stage and a high stage lesions. The optimal marker in one clone was 8q24.3 (Accuracy 0.7027, Sensitivity 0.9688, Specificity 0.5000), the optimal markers in two clones were 7q36.3 and 22q11.1 (Acc. 0.8108, Sen. 0.8438, Spe. 0.7857)…
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2009
File Version Version of Record
Access Rights open access
Relations
[isVersionOf] [URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools 大学院医学系研究科(医学)