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A Case with Neutrophil Infiltration into Nevus Cell Nest after Intravenous Administration of Interferon-β

The bulletin of the Yamaguchi Medical School Volume 42 Issue 1-2 Page 45-47
published_at 1995-12
A020042000107.pdf
[fulltext] 3.01 MB
Title
A Case with Neutrophil Infiltration into Nevus Cell Nest after Intravenous Administration of Interferon-β
Creators Mogami Satoshi
Creators Hirota Toru
Creators Nagai Ko
Creators Okimura Hiroshi
Creators Muto Masahiko
Creators Asagami Chidori
Source Identifiers
Creator Keywords
intradermal nevus interferon neutrophil anti-tumor effect
Interferon-β therapy has been widely applied for patients with hapatitis C and with malignant melanoma. Its anti-tumor effects on malignant melanoma are well discussed but few reports on anti-tumor effect of the interferon-β to benign tumors are described. A 63-year-old female received interferon-β therapy(dose=6×10 6 units/day) for hepatitis C and developed erythematous change and pain on her intradermal nevus seen on the right external canthus. Histopathological study revealed that the neutrophilic infiltration was localized only in nevus cell nest. It seems interferon-βworked on nevus cells and led the nevocytes to secrete cytokines such as IL-8. A possibility that there is one pathway on anti-tumor effects related to melanin-prpducing cells, via the neutrophils, is suggested.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1995-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部