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Inhibitory Effect of Tetrodotoxin on the Contractile Activity of the Guinea-pig Ileum and Distal Colon

The bulletin of the Yamaguchi Medical School Volume 20 Issue 3-4 Page 85-97
published_at 1973-12
A020020000302.pdf
[fulltext] 814 KB
Title
Inhibitory Effect of Tetrodotoxin on the Contractile Activity of the Guinea-pig Ileum and Distal Colon
Creators Ohkawa Hiromichi
Source Identifiers
1. Effects of tretrodotoxin, ganglion blocking drugs, cholonergic blocking drugs, adrenergic blocking drugs and junction potential blocking drugs on the contractile activity of intestine were investigated. 2. Tretradotoxin produced the distinct relaxation and inhibited the contractile activity of the guinea-pig ileum and distal colon while no inhibitation or slight increase in the contrastile activity of the guinea-pig taenia strip preparation, cat and rabibit ileum were observed. 3. Ganglion blocking drugs, hexa,ethonium, lidocaine and dibucaine, showed the inhibitory action on the guinea-pig distal colon. In constrast, potentiation in the contractile activity of the rabbit ileum was obserced except dibucaine. 4. All cholinergic blocking drugs produced the inhibitory effect on the guinea-pig distal colon. 5. No distinct change or slight increase effect of adrenergic blocking drugs were observed on the guina-pig distal colon, expect phenoxybenzamine. In rabbit ileum, the potentiation on the contractile activity was observed by adrenergic blocking drugs expect phenoxybenzamine. 6. The possibility which excitatory dominant in the intrinsic neurones of guineapig ileum and distal colon was discussed.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1973-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部