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The Effect of the Carcinogenesis and the presence of Neoplastic Cells on the Mitotic Activity of Oral Epithelia in Rats and Mice

The bulletin of the Yamaguchi Medical School Volume 17 Issue 1-2 Page 53-69
published_at 1970-06
A020017000105.pdf
[fulltext] 2.48 MB
Title
The Effect of the Carcinogenesis and the presence of Neoplastic Cells on the Mitotic Activity of Oral Epithelia in Rats and Mice
Creators Matsuki Kiyoshi
Source Identifiers
Using the rats fed DAB diet and the mice transplanted with Ehrlich ascites tumor, the relation between mitotic activity of the epithelium of the oral cavity and the presence of neoplastic cells was observed with colchicine technique. The epithelium of the oral cavity and the presence of neoplastic cells was observed with colchicine technique. The effect of anabolic steroid hormone was also examined. In the male rats received the ASH, the incidence of hepatoma was strictly lower than that of contral rats 150 days after administration of DAB. Mitotic rate of epithelial cells of buccal mucosa from hepatoma-bearing rats was inhibited more than that from non-hepatoma-bearing rats, and each of them was divided by a borderline of 2.0 per cent level. The tongue surface of mice transplanted with Ehrlich ascites tumor showed clearly higher mitotic activity in the group treated with ASH than in the nontreated group. Conversely, mitotic rate of Ehrlich ascites tumor cells was inhibited in the mice treated with ASH. From these results, it was discussed on mitosis stimulating agent in the process of carcinogenesis.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1970-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部