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Scanning and transmission electron microscopy of biodegradable microspheres (DSM) in blood vessels

Cell biology international reports Volume 13 Issue 5 Page 427-436
published_at 1989-05
Title
Scanning and transmission electron microscopy of biodegradable microspheres (DSM) in blood vessels
Creators Makita T.
Creators Kagabu Satoshi
Creators Kagabu S.
Creators Manba K.
Creators Naito I.
Creators Lindblom R.
Creators Hatsuoka M.
Creators Okawa T.
A type of biodegradable microsphere (DSM), approximately 45 um in diameter, made of polymerized potato starch (Pharmacia, Sweden) was intravenously injected into rats to observe the state of DSM in small blood vessels in the kidney and liver at the electron microscopic level. Prior to their digestion with amylase, individual DSM changed their round shape to an irregularly folded one to occupy almost the whole area of the lumen. At the transmission electron microscopic level, DSM were impregnated with colloidal iron and were easily identified. Interaction of the iron labelled DSM with the surface of endothelial cells was unexpectedly loose and no adherence or fusion of this surface was observed. The starch substance was not visible in the pinocytotic vesicles of the endothelium. These findings suggest the independent profile of DSM in situ.
Languages eng
Resource Type journal article
Publishers Elsevier
Date Issued 1989-05
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0309-1651
[NCID]AA00600025
https://doi.org/10.1016/0309-1651(89)90137-9
[isPartOf] [URI]http://www.sciencedirect.com/science/journal/03091651
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