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Changes of Serum GOT, GPT and Bilirubin Values after the Administration of α-Naphthylisothiocyanate in Rats and Dogs

Bulletin of the Faculty of Agriculture, Yamaguchi University Volume 37 Page 69-81
published_at 1989
Title
ラットおよびイヌにおけるα―ナフチルイソチオシアン酸投与後の血清GOT,GPT活性およびビリルビン値の動態
Changes of Serum GOT, GPT and Bilirubin Values after the Administration of α-Naphthylisothiocyanate in Rats and Dogs
Creators Shibata Hiroshi
Creators Katoh Hirotake
Source Identifiers
Changes of serum transaminse (GOT,GPT) and bilirubin values after a single oral or intraperitoneal administration of α-naphthylisothiocyanate (ANIT) were studied in rats and dogs. After the administration of ANIT, serum transaminase and bilirubin values increased with the increase in dose of ANIT in both rats and dogs, however, the degree of increase in these parameters was much lower in dogs than in rats. The degree of increase in the serum parameters after ANIT treatment in rats or dogs was similar in both oral and intraperitoneal administration. The administration of ANIT produced a marked cholestatic response in rats, but no cholestasis was produced in dogs even when high doses of ANIT were administered or the lapse of time after ANIT administration increased. These differences in response to ANIT between rats and dogs may be explained on the basis of different rates and/or pathways of biotransformation of ANIT.
Subjects
農学 ( Other)
Languages jpn
Resource Type departmental bulletin paper
Publishers 山口大学農学部
Date Issued 1989
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1715
[NCID]AN00244250
Schools 農学部