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Blood Clearance of ^<198>Au-colloid for Evaluation of Hepatic Dysfunction in Rats

Bulletin of the Faculty of Agriculture, Yamaguchi University Volume 36 Page 1-12
published_at 1998
Title
^<198>Au-コロイド血液クリアランスによるラット肝機能障害の評価
Blood Clearance of ^<198>Au-colloid for Evaluation of Hepatic Dysfunction in Rats
Creators Shibata Hiroshi
Creators Takagi Atsuya
Creators Hisano Tomoyuki
Source Identifiers
The fundamental study on availability of ^<198>Au-colloid clearance test for evaluation of hepatic dysfunction was carried out by using the normal rats or the carbon tetrachloride (CCI_4)-treated rats. It appeared appropriate to administer gold in ^<198>Au-colloid at the dose of 100 μg/kg in order to obtaion an effective blood clearance curve of ^<198>Au-clloid. The blood clearance curve of ^<198>Au-clloid showed two-phase changes, i.e., ^<198>Au-colloid concentration in blood rapidly decreased for the first 10 minutes, and slowly later on. The disappearance rate of ^<198>Au-colloid from blood decreased with the increase in dose of CCI_4. The decrease in the blood clearance of ^<198>Au-colloid by CCI_4 administration might be the consequence of the decrease in the uptake ratio of ^<198>Au-colloid into the liver. The blood clearance test of ^<198>Au-colloid might be one of more useful methods for evaluation of hepatic dysfunction in rats, equally to the indocyanine green (ICG) test.
Subjects
農学 ( Other)
Languages jpn
Resource Type departmental bulletin paper
Publishers 山口大学農学部
Date Issued 1998
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1715
[NCID]AN00244250
Schools 農学部