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Effects of Synthetic Peptide, Leu-Leu-Lys-Asp-Leu, on the Growth Hormone Induced Lipolysis

Bulletin of the Faculty of Agriculture, Yamaguchi University Volume 35 Page 43-52
published_at 1987
Title
合成ペプチド,Leu-Leu-Lys-Asp-Leuの成長ホルモンによる脂肪動員作用に対する効果
Effects of Synthetic Peptide, Leu-Leu-Lys-Asp-Leu, on the Growth Hormone Induced Lipolysis
Creators Ide Akio
Creators Soeda Mitsuo
Creators Yamasaki Nobuyuki
Creators Masuno Hiroshi
Creators Okuda Hiromichi
Source Identifiers
In order to explain the mechanism of the lipolysis induced by the growth hormone, several Lys-Asp derivatives have been synthesized and examined the lipolytic activity to the epididymal adipose tissue of rats. Lys-Asp derivatives having either alph-or epsilon-amino group at the N-terminal and carboxyl groups at the C-terminal were concerned to the lipolytic action. This activity was emphasized by allowance of appropriate hydrophobicity. A peptide suited to such conditions was conceived to be Leu-Leu-Lys-Asp-Leu whose sequence was found in the amino acid sequence of boving growth hormone. Therefore, it was suggested that peptide might have the lipolytic activity. Then a peptide, Leu-Leu-Lys-Asp-Leu, was synthesized by the stepwise method and
Subjects
農学 ( Other)
Languages jpn
Resource Type departmental bulletin paper
Publishers 山口大学農学部
Date Issued 1987
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1715
[NCID]AN00244250
Schools 農学部