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Difference in DNA copy number aberrations detected between Osteosarcoma and Malignant Fibrous Histiocytoma

The bulletin of the Yamaguchi Medical School Volume 50 Issue 1-4 Page 57-64

published_at 2003-12

A020050000108.pdf

[fulltext] 286 KB

Title

Difference in DNA copy number aberrations detected between Osteosarcoma and Malignant Fibrous Histiocytoma

Creators Ohi Ritsuko

Source Identifiers

Creator Keywords

comparetive genomic hybridization DNA copy number aberrations osteosarcoma malignant fibrous histiocytoma differential diagnosis

Osteosarcoma (OS) and malignant fibrous histiocytoma (MFH) are the most frequent sarcomas of the bones and soft tissues, respectivery. These tumors share a spectrum of histpathologic features. In order to elucidate the similarity and difference of tumor-specific genetic alterations between them, we analyzed DNA copy number aberrations of 7 Oss and 12 MFHs using comparative genomic hybridization (CGH). In OS a DNA copy number gain of chromosome 1p21-pter was the most frequent aberration (85.7%

Subjects

医学 ( Other)

Languages eng

Resource Type departmental bulletin paper

Publishers Yamaguchi University Graduate School of Medicine

Date Issued 2003-12

File Version Version of Record

Access Rights open access

Relations

[ISSN]0513-1812

[NCID]AA00594272

Schools 医学部