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Difference in DNA copy number aberrations detected between Osteosarcoma and Malignant Fibrous Histiocytoma

The bulletin of the Yamaguchi Medical School Volume 50 Issue 1-4 Page 57-64
published_at 2003-12
A020050000108.pdf
[fulltext] 286 KB
Title
Difference in DNA copy number aberrations detected between Osteosarcoma and Malignant Fibrous Histiocytoma
Creators Ohi Ritsuko
Source Identifiers
Creator Keywords
comparetive genomic hybridization DNA copy number aberrations osteosarcoma malignant fibrous histiocytoma differential diagnosis
Osteosarcoma (OS) and malignant fibrous histiocytoma (MFH) are the most frequent sarcomas of the bones and soft tissues, respectivery. These tumors share a spectrum of histpathologic features. In order to elucidate the similarity and difference of tumor-specific genetic alterations between them, we analyzed DNA copy number aberrations of 7 Oss and 12 MFHs using comparative genomic hybridization (CGH). In OS a DNA copy number gain of chromosome 1p21-pter was the most frequent aberration (85.7%
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 2003-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部