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Clinical Experience with Cefazolin in Large Doses Combined with Aminoglycoside in Blood Disease

The bulletin of the Yamaguchi Medical School Volume 22 Issue 4 Page 693-702
published_at 1975-12
A020022000406.pdf
[fulltext] 628 KB
Title
Clinical Experience with Cefazolin in Large Doses Combined with Aminoglycoside in Blood Disease
Creators Oda Susumu
Creators Ariyoshi Kunio
Creators Shiomura Tadahiko
Creators Tajiri Mitsuaki
Creators Ono Junichiro
Creators Nakashima Koji
Source Identifiers
The clinical efficacy of cefazolin (8-12g. daily) combined with amin-oglycoside for severe infection was evaluated in 20 patients with blood diseases. In ten of twenty patients, therapeutic success was achieved. Three patients with infection of which the causative organism was not detected responded to cefazolin alone or with gentamicin. But the usual dose of cefazolin (2-4g. daily) was not effective against infections due to gram-negative bacilli in a patient with Hodgkin's disease although there were sufficient neutrophil count. As mixed infection with organisms which were insensitive to cefazolin were frequently observed in patients with neutropenia or malignant blood diseases and most of cefazolin-insensitive organisms were sensitive to aminoglycoside, aminoglycoside should be included in the initial therapy of CEZ in large doses for severe infection due to gram-negative bacilli in these patients. There were no significant side effects except for one case of generalized exanthemas associated with cefazolin ill large dose combined with aminoglycoside.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1975-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部