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Prophylactic activity of ivermectin against Dirofilaria immitis infection in dogs: Larvicidal activity of ivermectin against D. immitis larvae 30 days after Infection

Japanese journal of veterinary science Volume 49 Issue 1 Page 115-120
published_at 1987
2008010284.pdf
[fulltext] 500 KB
Title
Prophylactic activity of ivermectin against Dirofilaria immitis infection in dogs: Larvicidal activity of ivermectin against D. immitis larvae 30 days after Infection
Creators Ohishi Isamu
Creators Katae Hiromi
Creators Hayasaki Mineo
Creators Tada Yusuke
Creator Keywords
Dirofilaria immitis dog ivermectin larvicidal activity
Larvicidal activity of ivermectin against Dirofilaria immitis larvae of 30 days old was evaluated. A single oral dose of ivermectin to demonstrate complete larvicidal activity was 3μg/kg of body weight or more. Administrations of ivermectin at 0.5, 1 and 2μg/kg dose-relatedly showed incomplete antilarval activities. Administration of ivermectin at 0.5, 1 and 2μg/kg 30 days after infection caused lower levels of the sex ratios (female/male) than that of the control showing definite decrease in numbers of female worms. The average body lengths of both female and male worms recovered from dogs receiving ivermectin at 0.5, 1 and 2μg/kg, except for that of female worms at 1μg/kg, were significantly shorter than that of the worms recovered from the control dogs.
Languages eng
Resource Type journal article
Publishers 日本獣医学会
Date Issued 1987
File Version Version of Record
Access Rights open access
Relations
[ISSN]0021-5295
[NCID]AA10521639
[isVersionOf] [URI]http://www.jstage.jst.go.jp/browse/jvms/-char/ja
[isVersionOf] Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis [URI]http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2010010511
Schools 農学部